2017 ACVIM Forum Research Abstract Program

Liver disease in cats prolongs the half-life of mirtazapine. Dosing with a decreased frequency should be considered in cats with liver disease. As this effect was quite variable, additional work will need to be done to determine which cats are most effected. Esomeprazole is an S-enantiomer of omeprazole that has been reported to have more favourable pharmacokinetics and efficacious antacid properties in humans. However, there is little information about the dosage of esomeprazole and pharmacokinetic property in conscious dogs. The aim was to evaluate the efficacy of intravenous esomeprazole q12 h and to compare the efficacy between 1 mg/kg and 0.5 mg/kg in healthy dogs.