2017 ACVIM Forum Research Abstract Program

This study suggests individual variation in aspirin response does exist in dogs as assessed by multiple electrode aggregometry. A single low dose (4 mg/kg) of aspirin was not sufficient to cause measurable inhibition of platelet aggregation in all dogs and resulted in ASA concentrations that were substantially less than those used in vitro. Aspirin responsiveness in vitro did not correlate with responsiveness in vivo in this scenario. The use of EDTA fluoride anticoagulant resulted in inhibition of conversion of ASA to SA suggesting successful inhibition of esterase activity. When storing dog plasma samples containing aspirin, the use of EDTA containing fluoride may prevent esterase hydrolysis of the ASA. Further investigation into the effects of esterase activity as a cause of aspirin resistance in dogs is warranted. Sildenafil citrate, a highly selective phosphodiesterase type V inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. Sometimes, patients with PH experience respiratory distress, and the oral administration of any type of drug to these patients can be fatal. For such patients, the rectal route should be carefully considered as an alternative means of administering drugs.