Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_782
Snippet: SLN was the predominant regulatory micropeptide in gluteal muscle with several hundred fold higher gene expression than PLB or MRLN. Unlike all other studied mammalian species, equine SLN encoded a truncated protein (29 vs 31 amino acids) missing key regulatory residues (Ser4, Thr5, Cys9, Tyr31) that are proposed to mediate controlled, reversible SERCA inhibition. In contrast, equine MLN had one conservative amino acid substitution, DWORF 2 non-c.....
Document: SLN was the predominant regulatory micropeptide in gluteal muscle with several hundred fold higher gene expression than PLB or MRLN. Unlike all other studied mammalian species, equine SLN encoded a truncated protein (29 vs 31 amino acids) missing key regulatory residues (Ser4, Thr5, Cys9, Tyr31) that are proposed to mediate controlled, reversible SERCA inhibition. In contrast, equine MLN had one conservative amino acid substitution, DWORF 2 non-conservative amino acid substitutions and PLN was 100% orthologous to other species. Non-synonymous mutations in SLN, MLN or DWORF were not identified in RER horses compared to control horses.
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