2017 ACVIM Forum Research Abstract Program

Pharmacokinetic analysis revealed peak concentration (C max ) of 11.05 AE 5.26 lg/mL, time of maximum concentration (T max ) of 2.83 AE 1.33 h, area under the curve (AUC) of 92.2 AE 48.9 lg*h/ mL, and an elimination half-life (T 1/2 ) of 9.11 AE 1.5 h. Significantly increased concentrations of creatinine (pre: median of 1.65 mg/dL and range of 1.5-1.8 mg/dL, post: median of 2 mg/dL and range of 1.9-2.3 mg/dL; P = 0.02) and bicarbonate (pre: median of 22.8 mmol/L and range of 17.6-25.3 mmol/L, post: median of 30.7 mmol/L and range of 27.6-34 mmol/L; P = 0.0007) were noted. Chloride concentrations were markedly decreased (pre: median of 99 mmol/L and range of 96-103 mmol/L, post: median of 87.5 mmol/L and range of 85-88 mmol/L; P = 0.0007).