2017 ACVIM Forum Research Abstract Program

Infusions with hypertonic glucose resulted in marked hyperglycemia and hyperinsulinemia but cK remained unchanged during the first 20 minutes after initiation of treatment. Between 30 and 120 min after start of treatment the most marked decrement of cK was observed in hypertonic NaHCO 3 , with values that differed significantly (P < 0.05) from hypertonic NaCl, but not from hypertonic Glucose. After 120 min the observed decrements were equivalent to À26 AE 10%, À9 AE 8%, and À22 AE 6% of baseline cK in groups NaHCO 3 , NaCl, and Glucose, respectively. Results indicate a treatment advantage of hypertonic NaHCO 3 -infusions over the use of hypertonic NaCl or glucose in hyperkalemic diarrheic calves, with alkalinization providing the most effective potassium-lowering mechanism. Calfhood diseases have a major economic impact on beef and dairy operations, due to the costs associated with mortality, treatment and the long term effects on growth and performance. With very few approved drugs for use in veal calves and young heifers, questions remain about the distribution and effectiveness of these drugs in young animals. The objective of this study was to compare the distribution of active drug concentrations in the plasma vs. different effector compartments including interstitial fluid (ISF) and pulmonary epithelial lining fluid (PELF) of healthy 3-weekold and 6-month-old calves.