Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_803
Snippet: Six normal horses received topical 1% voriconazole (VORI-TOP) every 4 hours for 2 days, and then subconjunctival injection of 1.5% VORI-GEL after washout in alternate eyes. Tears and AH were collected day 2 in VORI-TOP and days 2, 7, 14, and 23 in VORI-GEL. To evaluate ocular tissue concentrations, 2 horses received a subconjunctival injection of 1.5% VORI-GEL 2 days and 2 hrs before euthanasia in alternate eyes. Voriconazole concentrations were .....
Document: Six normal horses received topical 1% voriconazole (VORI-TOP) every 4 hours for 2 days, and then subconjunctival injection of 1.5% VORI-GEL after washout in alternate eyes. Tears and AH were collected day 2 in VORI-TOP and days 2, 7, 14, and 23 in VORI-GEL. To evaluate ocular tissue concentrations, 2 horses received a subconjunctival injection of 1.5% VORI-GEL 2 days and 2 hrs before euthanasia in alternate eyes. Voriconazole concentrations were measured by high performance liquid chromatography, and evaluated using Student's t-tests and descriptive statistics. Ocular inflammation was assessed using a modified Hackett-McDonald scoring system.
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