2017 ACVIM Forum Research Abstract Program

Subconjunctival injection of VORI-GEL is safe. In normal horses, low AH and tear concentrations are likely due to intact ocular barriers and high drug lipophilicity. There is sustained release of therapeutic concentrations of voriconazole from the VORI-GEL to the anterior segment tissues for at least 2 days following injection. A diagnosis of inflammatory airway disease (IAD) is commonly based on abnormal bronchoalveolar lavage fluid (BALF) cytology or airway hyperreactivity (AHR) in horses with poor performance or chronic cough. Our study purpose was to determine whether two modalities of non-invasive lung function testing (FOM-forced oscillatory mechanics vs. RIP-Respiratory Inductive Plethysmography) establish the same clinical diagnosis of AHR, using histamine bronchoprovocation. AHR was defined by the histamine dose needed to double FOM baseline resistance, or to achieve a 35% increase in RIP delta flow.