Author: Wassenaar, T.M.; Zou, Y.
Title: 2019_nCoV/SARS-CoV-2: rapid classification of betacoronaviruses and identification of Traditional Chinese Medicine as potential origin of zoonotic coronaviruses Document date: 2020_2_28
ID: rq9hmjsx_8
Snippet: In a pilot experiment, all coding regions of four virus species representing three subgenera (MERS-CoV for Merbecovirus, human coronavirus OC43 for Embecovirus and SARS-CoV and 2019_nCoV for Sarbecovirus) were compared by multiple alignment of nucleotide sequences. This did not identify any region that was sufficiently conserved to potentially design an RNA-two-primer amplification detection target for all betacoronavirus genera, which we had set.....
Document: In a pilot experiment, all coding regions of four virus species representing three subgenera (MERS-CoV for Merbecovirus, human coronavirus OC43 for Embecovirus and SARS-CoV and 2019_nCoV for Sarbecovirus) were compared by multiple alignment of nucleotide sequences. This did not identify any region that was sufficiently conserved to potentially design an RNA-two-primer amplification detection target for all betacoronavirus genera, which we had set as our initial goal to identify. It is clear that addition of the genomes of more virus species would only decrease conservation further.
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