2017 ACVIM Forum Research Abstract Program

IV and SC administration of esomeprazole may be useful when PO administration is not possible. No significant adverse effects were observed. Acetylsalicylic acid (ASA), commonly known as aspirin, is a cyclooxygenase inhibitor frequently used to inhibit platelet function and formation of thromboemboli in at risk patients. A potential phenomenon of resistance to these antiplatelet effects has been documented in people and potentially in dogs. Aspirin resistance may be a contributing factor to the development of life threatening thrombi thus increasing the rate of morbidity and mortality in several canine diseases. Understanding the phenomenon of aspirin resistance and developing methods for predicting it could lead to improvements in survival in these patients. The cause of aspirin resistance remains unclear. Individual variability in esterase activity and therefore hydrolysis of aspirin has been suggested as a potential cause of poor bioavailability of aspirin in blood in people.