2017 ACVIM Forum Research Abstract Program

EFFECT OF ULTRAFILTRATION DURING CARDIOPUL-MONARY BYPASS IN DOGS UNDERGOING MITRAL VALVE PLASTY. K. Matsuura 1 , S. Yamada 2 , M. Enokizono 3 , H. Suzuki 4 , D. Nagakubo 5 , N. Kanno 6 . 1 Animal Cardiovascular and Thoracic Surgery Center, Sayama-shi, Saitama, Japan, 2 Animal Cardiovascular and Thoracic Surgery, Fuchuu, Tokyo, Japan, 3 Japan Small Animal Medical Center, Tokorozawa, Saitama, Japan, 4 Animal cardiovascular and Thoracic Surgery Center, Sayama, Saitama, Japan, 5 The University of Tokyo, Sayama, Saitama, Japan, 6 Nihon University, Fujisawa, Kanagawa, Japan Cardiopulmonary bypass(CPB) is necessary to perform mitral valve plasty(MVP) in dogs. Ultrafiltration (UF) has major advantages such as reducing the amount of blood transfusion and removal of various cytokines in human medicine. We performed MVP for dogs with spontaneous mitral valve regurgitation(MR) under CPB and investigated the effect of ultrafiltration. Twentytwo dogs diagnosed with severe MR that underwent MVP under CPB were included. Depending on whether or not ultrafiltration was used, it was divided into a non-UF group and a UF group. We performed CUF (Conventional Ultrafiltration) and MUF (Modified Ultrafiltration). The lowest hematocrit (Ht) value and Ht after the end of CPB in both groups were compared. The average of the lowest Ht during the operation was 23.0% in the non-UF (n = 11) group and 24.0% in the UF group (n = 11), and no significant difference was observed between the two groups. The average Ht after the end of the CPB was 29.0% in the non-UF group and 35.5% in the UF group. Thus the average Ht was significantly higher in the UF group (P = 0.01). We also analyzed cases with low body weight (5 kg or less) separately. There were 6 such cases in the non-UF group and 9 low body weight cases in the UF group. The lowest Ht and the Ht after the end of the CPB was significantly higher in the UF group. Notably, the average Ht after the CPB was 10% higher in UF group (36.0%) than in non-UF group (26.0%).The amount of cardioplegia sufficient to produce cardiac arrest varies depending on the specific case. This often results in excessive hemodilution. Since it helps to drain excess fluids under such circumstances, CUF is thought to contribute to the difference in Ht in this study. In addition, during MUF, residual blood in the extracorporeal circuit can be returned to the patient's body. As a result, the Ht after the end of the CPB were higher in the UF group than in the non-UF group. We conclude that UF during CPB increases the lowest Ht value during CPB and increases Ht after end of the CPB in dogs undergoing MVP. These difference are particularly noticeable in small dogs. T. Morita 1 , K. Nakamura 2 , T. Osuga 1 , K. Morishita 2 , N. Sasaki 2 , H. Ohta 2 , M. Takiguchi 2 . 1 Hokkaido University, Sapporo, Hokkaido, Japan, 2 Department of Veterinary Clinical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan Right ventricular (RV) dysfunction and dyssynchrony have been associated with decreased cardiac function and clinical worsening in human patients with pre-capillary pulmonary hypertension (PH). However, few reports are available on RV function and dyssynchrony in dogs with pre-capillary PH. The objective of this retrospective study was to investigate RV morphological change, function and dyssynchrony assessed by echocardiography in dogs with pre-capillary PH.