Title: A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein Document date: 1991_10_1
ID: s4a8zs5a_40
Snippet: The Gml chimeric protein provides strong evidence that ml contains retention information . The finding that two of the mutations in ml that released retention of Om2,3 (Om2,3/ QI37 and Om2,3/ins) also allowed efficient transport of Gml to the cell surface supports the idea that Gml is retained specifically. It is unlikely that the single glutamine to isoleucine change in the middle ofthe membrane-spanning domain of Gm1QI would prevent misfolding .....
Document: The Gml chimeric protein provides strong evidence that ml contains retention information . The finding that two of the mutations in ml that released retention of Om2,3 (Om2,3/ QI37 and Om2,3/ins) also allowed efficient transport of Gml to the cell surface supports the idea that Gml is retained specifically. It is unlikely that the single glutamine to isoleucine change in the middle ofthe membrane-spanning domain of Gm1QI would prevent misfolding of Gml. It is more likely that this glutamine residue is a key component of the retention signal, and its replacement eliminates retention .
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