Selected article for: "cov sequence and SARS cov"
Author: Agnihothram, Sudhakar; Yount, Boyd L.; Donaldson, Eric F.; Huynh, Jeremy; Menachery, Vineet D.; Gralinski, Lisa E.; Graham, Rachel L.; Becker, Michelle M.; Tomar, Sakshi; Scobey, Trevor D.; Osswald, Heather L.; Whitmore, Alan; Gopal, Robin; Ghosh, Arun K.; Mesecar, Andrew; Zambon, Maria; Heise, Mark; Denison, Mark R.; Baric, Ralph S.
Title: A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant
  • Document date: 2014_3_25
    • ID: y4zoyqua_11
    Snippet: Protease inhibitors targeting MERS-CoV 3CLpro inhibit Bt-CoV HKU5-SE in vitro. Small molecule inhibitors targeting 3CLpro efficiently block SARS-CoV replication (22, 23) . With the 82% sequence similarity between the nsp5 proteins of MERS-CoV and BtCoV HKU5-SE, we are well positioned to identify broadly reactive group 2c protease inhibitors, which is important because there are significant functional and regulatory differences in the nsp5 protein.....
    Document: Protease inhibitors targeting MERS-CoV 3CLpro inhibit Bt-CoV HKU5-SE in vitro. Small molecule inhibitors targeting 3CLpro efficiently block SARS-CoV replication (22, 23) . With the 82% sequence similarity between the nsp5 proteins of MERS-CoV and BtCoV HKU5-SE, we are well positioned to identify broadly reactive group 2c protease inhibitors, which is important because there are significant functional and regulatory differences in the nsp5 proteins of different subgroups (2a, 2b, and 2c) but strong conservation of determinants within subgroups (14) .

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