Author: Usui, Kimihito; Ichihashi, Norikazu; Yomo, Tetsuya
Title: A design principle for a single-stranded RNA genome that replicates with less double-strand formation Document date: 2015_9_18
ID: znhvdtg8_17
Snippet: To investigate the effect of structures and nucleotide compositions on the dsRNA formation, we designed 28 RNAs with various secondary structures and nucleotide compositions and inserted the RNAs into position 63-64 of a 222nt RNA (MDV-1), a replicable template for Q⤠replicase ( Figure 2 , Supplementary Table S1). These inserts were designed not to destruct the secondary structures of MDV-1 and to preferably form only a single stable structure.....
Document: To investigate the effect of structures and nucleotide compositions on the dsRNA formation, we designed 28 RNAs with various secondary structures and nucleotide compositions and inserted the RNAs into position 63-64 of a 222nt RNA (MDV-1), a replicable template for Q⤠replicase ( Figure 2 , Supplementary Table S1). These inserts were designed not to destruct the secondary structures of MDV-1 and to preferably form only a single stable structure, except for RNAs 23-28, which were designed to form two different stable structures.
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