Author: Usui, Kimihito; Ichihashi, Norikazu; Yomo, Tetsuya
Title: A design principle for a single-stranded RNA genome that replicates with less double-strand formation Document date: 2015_9_18
ID: znhvdtg8_2
Snippet: A serious problem for using ssRNA as a genome is the formation of double-stranded RNA (dsRNA), which occurs during replication. For recursive replication, an ss-RNA genome must replicate as a single strand; however, the proximity of the newly synthesized strand to the template genome at replication would lead to formation of dsRNA through hybridization. This dsRNA formation is a problem for recursive replication in the RNA world (3) and is one of.....
Document: A serious problem for using ssRNA as a genome is the formation of double-stranded RNA (dsRNA), which occurs during replication. For recursive replication, an ss-RNA genome must replicate as a single strand; however, the proximity of the newly synthesized strand to the template genome at replication would lead to formation of dsRNA through hybridization. This dsRNA formation is a problem for recursive replication in the RNA world (3) and is one of the most serious problems in the reconstitution of a replication system of an artificial ssRNA genome (4, 5) .
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