Author: Marty, Francisco M; Chemaly, Roy F; Mullane, Kathleen M; Lee, Dong-Gun; Hirsch, Hans H; Small, Catherine B; Bergeron, Anne; Shoham, Shmuel; Ljungman, Per; Waghmare, Alpana; Blanchard, Elodie; Kim, Yae-Jean; McKevitt, Matt; Porter, Danielle P; Jordan, Robert; Guo, Ying; German, Polina; Boeckh, Michael; Watkins, Timothy R; Chien, Jason W; Dadwal, Sanjeet S
Title: A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract Document date: 2019_12_3
ID: sl45z4i0_37
Snippet: In summary, presatovir treatment was generally well tolerated in HCT recipients with naturally acquired RSV LRTI but did not achieve virologic or clinical endpoints. The tendency of adults with naturally acquired RSV infection to seek treatment only after several days of symptoms, when the treatment window may have closed for fusion inhibitors in particular, is a challenge for clinical trials of RSV-specific antiviral therapies. The numerically l.....
Document: In summary, presatovir treatment was generally well tolerated in HCT recipients with naturally acquired RSV LRTI but did not achieve virologic or clinical endpoints. The tendency of adults with naturally acquired RSV infection to seek treatment only after several days of symptoms, when the treatment window may have closed for fusion inhibitors in particular, is a challenge for clinical trials of RSV-specific antiviral therapies. The numerically lower rate of pulmonary complications in the presatovir URTI trial suggests that early treatment, before LRTI develops, is key for success in future studies. Acute kidney injury 0 2 (6.9)
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