Author: Marty, Francisco M; Chemaly, Roy F; Mullane, Kathleen M; Lee, Dong-Gun; Hirsch, Hans H; Small, Catherine B; Bergeron, Anne; Shoham, Shmuel; Ljungman, Per; Waghmare, Alpana; Blanchard, Elodie; Kim, Yae-Jean; McKevitt, Matt; Porter, Danielle P; Jordan, Robert; Guo, Ying; German, Polina; Boeckh, Michael; Watkins, Timothy R; Chien, Jason W; Dadwal, Sanjeet S
Title: A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract Document date: 2019_12_3
ID: sl45z4i0_11
Snippet: For virology assessments, bilateral intranasal samples were obtained using midturbinate adult flocked swabs (Copan Diagnostics, Murrieta, CA, USA) at each study visit [19, 20] . Samples were analyzed using reverse transcription quantitative polymerase chain reaction (RT-qPCR) to determine RSV viral load, RSV sequencing of the F gene to evaluate development of resistance, and a multiplex assay to identify coinfections. All nasal samples were analy.....
Document: For virology assessments, bilateral intranasal samples were obtained using midturbinate adult flocked swabs (Copan Diagnostics, Murrieta, CA, USA) at each study visit [19, 20] . Samples were analyzed using reverse transcription quantitative polymerase chain reaction (RT-qPCR) to determine RSV viral load, RSV sequencing of the F gene to evaluate development of resistance, and a multiplex assay to identify coinfections. All nasal samples were analyzed at central laboratories; further details are provided in Supplemental methods. Antibody titer and pharmacokinetic methods are described in Supplemental methods.
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