Author: Qin, E’de; He, Xionglei; Tian, Wei; Liu, Yong; Li, Wei; Wen, Jie; Wang, Jingqiang; Fan, Baochang; Wu, Qingfa; Chang, Guohui; Cao, Wuchun; Xu, Zuyuan; Yang, Ruifu; Wang, Jing; Yu, Man; Li, Yan; Xu, Jing; Si, Bingyin; Hu, Yongwu; Peng, Wenming; Tang, Lin; Jiang, Tao; Shi, Jianping; Ji, Jia; Zhang, Yu; Ye, Jia; Wang, Cui’e; Han, Yujun; Zhou, Jun; Deng, Yajun; Li, Xiaoyu; Hu, Jianfei; Wang, Caiping; Yan, Chunxia; Zhang, Qingrun; Bao, Jingyue; Li, Guoqing; Chen, Weijun; Fang, Lin; Li, Changfeng; Lei, Meng; Li, Dawei; Tong, Wei; Tian, Xiangjun; Wang, Jin; Zhang, Bo; Zhang, Haiqing; Zhang, Yilin; Zhao, Hui; Zhang, Xiaowei; Li, Shuangli; Cheng, Xiaojie; Zhang, Xiuqing; Liu, Bin; Zeng, Changqing; Li, Songgang; Tan, Xuehai; Liu, Siqi; Dong, Wei; Wang, Jun; Wong, Gane Ka-Shu; Yu, Jun; Wang, Jian; Zhu, Qingyu; Yang, Huanming
Title: A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China Document date: 2016_11_28
ID: uqv2ydk8_10
Snippet: Based on comparative analyses on the complete genome sequences of the 17 SARS-CoV isolates from patients identified in Canada, USA, Singapore, and China (Beijing, Zhejiang, Guangdong, Hong Kong, and Taiwan), an unrooted phylogenetic tree of the SARS-CoV was constructed (Figure 2). The phylogenetic tree positioned Isolate GD01 in the group composed of BJ01, 02, 03, and 04, two of the Hong Kong isolates (CUHK), and the US isolate (Urbani). This par.....
Document: Based on comparative analyses on the complete genome sequences of the 17 SARS-CoV isolates from patients identified in Canada, USA, Singapore, and China (Beijing, Zhejiang, Guangdong, Hong Kong, and Taiwan), an unrooted phylogenetic tree of the SARS-CoV was constructed (Figure 2). The phylogenetic tree positioned Isolate GD01 in the group composed of BJ01, 02, 03, and 04, two of the Hong Kong isolates (CUHK), and the US isolate (Urbani). This paradigm suggests a possible transmission path among Guangdong, Hong Kong, Beijing and USA. The link between the two isolates (TOR2 and HKU) in another group has been suggested that the Toronto patient, from whom the isolate was obtained, was known to have traveled from Hong Kong (3). In addition, the five isolates identified in Singapore seem to form another group. Two relatively distant isolates in Taiwan and Zhejiang, China, reported more recently, are more distant from the rest. Additional molecular epidemiological data, based on genomic sequences of viral isolates identified from different regions, is essential to elucidate the possible routes of global spreading and mutation during its transmission among humans.
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