Author: Hawkins, John A.; Kaczmarek, Maria E.; Müller, Marcel A.; Drosten, Christian; Press, William H.; Sawyer, Sara L.
Title: A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species Document date: 2019_6_4
ID: telmxmp4_40
Snippet: Multiple Sequence Alignments and Best Genomic Isoforms. Multiple sequence alignments were generated on amino acid sequences with MAFFT L-INS-i, the slower but more accurate version of the popular MAFFT alignment software (98) . Manual inspection revealed that while the HMMER models had quite consistently found the same isoform from all of the transcriptomic datasets, the genomic data were slightly less consistent. This is not surprising, as diffe.....
Document: Multiple Sequence Alignments and Best Genomic Isoforms. Multiple sequence alignments were generated on amino acid sequences with MAFFT L-INS-i, the slower but more accurate version of the popular MAFFT alignment software (98) . Manual inspection revealed that while the HMMER models had quite consistently found the same isoform from all of the transcriptomic datasets, the genomic data were slightly less consistent. This is not surprising, as different species can have different annotated longest isoforms. So, for each gene in each species with genomic data, we went back and found the isoform most similar to the consensus isoform.
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