Author: Agnihothram, Sudhakar; Yount, Boyd L.; Donaldson, Eric F.; Huynh, Jeremy; Menachery, Vineet D.; Gralinski, Lisa E.; Graham, Rachel L.; Becker, Michelle M.; Tomar, Sakshi; Scobey, Trevor D.; Osswald, Heather L.; Whitmore, Alan; Gopal, Robin; Ghosh, Arun K.; Mesecar, Andrew; Zambon, Maria; Heise, Mark; Denison, Mark R.; Baric, Ralph S.
Title: A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant Document date: 2014_3_25
ID: y4zoyqua_27
Snippet: Mouse adaptation of BtCoV HKU5-SE resulted in increased viral replication and greater virulence in aged mice. Additionally, animals developed interstitial pneumonia with hyaline membrane formation. Mutations in nsp13, nsp14, ORF5, and ORF7 (M) genes were associated with increased virulence phenotypes in aged mice. Interestingly, evolution in the nsp13, nsp14, and M genes was also reported following SARS-CoV passage in mice (20, 25, 47) and humans.....
Document: Mouse adaptation of BtCoV HKU5-SE resulted in increased viral replication and greater virulence in aged mice. Additionally, animals developed interstitial pneumonia with hyaline membrane formation. Mutations in nsp13, nsp14, ORF5, and ORF7 (M) genes were associated with increased virulence phenotypes in aged mice. Interestingly, evolution in the nsp13, nsp14, and M genes was also reported following SARS-CoV passage in mice (20, 25, 47) and humans during the expanding epidemic, which suggests that they play critical roles in cross-species adaptation, replication, and pathogenesis (48) .
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