Selected article for: "Animal model and MERS cov pathogenesis"
Author: Agnihothram, Sudhakar; Yount, Boyd L.; Donaldson, Eric F.; Huynh, Jeremy; Menachery, Vineet D.; Gralinski, Lisa E.; Graham, Rachel L.; Becker, Michelle M.; Tomar, Sakshi; Scobey, Trevor D.; Osswald, Heather L.; Whitmore, Alan; Gopal, Robin; Ghosh, Arun K.; Mesecar, Andrew; Zambon, Maria; Heise, Mark; Denison, Mark R.; Baric, Ralph S.
Title: A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant
  • Document date: 2014_3_25
    • ID: y4zoyqua_3
    Snippet: The lack of a small animal model for MERS-CoV has limited the understanding of the pathogenesis of ␤-CoVs belonging to subgroup 2c, thereby hampering the development of vaccines and therapeutics. BtCoV HKU5 shares a high degree of genetic sequence identity with MERS-CoV in the replicase targets and N genes. Therefore, developing a small animal model will assist us to identify viral determinants of pathogenesis and virulence, explore the possibi.....
    Document: The lack of a small animal model for MERS-CoV has limited the understanding of the pathogenesis of ␤-CoVs belonging to subgroup 2c, thereby hampering the development of vaccines and therapeutics. BtCoV HKU5 shares a high degree of genetic sequence identity with MERS-CoV in the replicase targets and N genes. Therefore, developing a small animal model will assist us to identify viral determinants of pathogenesis and virulence, explore the possibility of vaccine-induced eosinophilia for MERS-CoV vaccines, and identify antivirals with broad activity against subgroup 2c strains. Furthermore, to date, no subgroup 2c bat CoVs have been cultured in vitro; the availability of infectious clones of these viruses will help us to dissect common evolutionary relationships among pathogenic CoV strains.

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