Author: Liu, Chunxi; Liu, Tingxian; Yu, Xiaoyue; Gu, Yizhu
Title: A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells Document date: 2017_4_1
ID: xio0g203_60
Snippet: It was reported the different functions of CD13 were independent of each other. For example, the antibodies that target coronavirus-binding sites on CD13 can potentially block coronavirus infections, without interfering with the physiological functions of CD13. It was demonstrated that coronaviruses had evolved a mechanism to use CD13 as their cell entry receptor without interfering with the physiological functions of this important host enzyme 4.....
Document: It was reported the different functions of CD13 were independent of each other. For example, the antibodies that target coronavirus-binding sites on CD13 can potentially block coronavirus infections, without interfering with the physiological functions of CD13. It was demonstrated that coronaviruses had evolved a mechanism to use CD13 as their cell entry receptor without interfering with the physiological functions of this important host enzyme 46 . In this study, the results further verified that the internalization of TPIC by HUVEC was not dependent on the enzyme activity of CD13, implying that TPIC might also use CD13 as their cell entry receptor without interfering with the physiological functions in the same way as coronaviruses do.
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