Author: Ranjbar, Shahin; Haridas, Viraga; Jasenosky, Luke D.; Falvo, James V.; Goldfeld, Anne E.
Title: A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection Document date: 2015_10_22
ID: zy82bo7q_13
Snippet: To investigate the relative impact of each IFITM family member on MTb growth in monocytes, we next overexpressed IFITM1, IFITM2, or IFITM3 in THP-1 cells by lentiviral transduction ( Figure S3 ). At 24 hr post-infection, H37Rv-mCherry signal was lower in each IFITM-overexpressing cell line compared to cells transduced with an empty lentiviral vector ( Figure 3A ). As shown in Figure 3A , IFITM3 overexpression led to the greatest decrease in MTb g.....
Document: To investigate the relative impact of each IFITM family member on MTb growth in monocytes, we next overexpressed IFITM1, IFITM2, or IFITM3 in THP-1 cells by lentiviral transduction ( Figure S3 ). At 24 hr post-infection, H37Rv-mCherry signal was lower in each IFITM-overexpressing cell line compared to cells transduced with an empty lentiviral vector ( Figure 3A ). As shown in Figure 3A , IFITM3 overexpression led to the greatest decrease in MTb growth (38.5% compared to 26.7% for IFITM1 and 24.7% for IFITM2).
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