Selected article for: "cell surface and TPIC internalization"
Author: Liu, Chunxi; Liu, Tingxian; Yu, Xiaoyue; Gu, Yizhu
Title: A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells
  • Document date: 2017_4_1
    • ID: xio0g203_50
    Snippet: After MβCD treatment, the co-localization of TPIC and CAV1 was also evaluated to further determine the important role of caveolae in TPIC internalization. As shown in Fig. 6C , the colocalization of TPIC and CAV1 decreased significantly by pretreatment with MβCD. Without MβCD, CAV1 and TPIC colocalized at the perinuclear area to a large extent. However, after MβCD treatment, cell cholesterol was depleted and the integrity of the caveolae was .....
    Document: After MβCD treatment, the co-localization of TPIC and CAV1 was also evaluated to further determine the important role of caveolae in TPIC internalization. As shown in Fig. 6C , the colocalization of TPIC and CAV1 decreased significantly by pretreatment with MβCD. Without MβCD, CAV1 and TPIC colocalized at the perinuclear area to a large extent. However, after MβCD treatment, cell cholesterol was depleted and the integrity of the caveolae was destroyed. Thereby, the distribution of CAV1 became discontinuous on the cell surface and gathered into a cluster. Consequently, the extent of the co-localization of TPIC and CAV1 was greatly reduced, and only a small number of overlapping spots appeared, suggesting the important effect of caveolae on the internalization of TPIC.

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