Selected article for: "cell surface and co CAV1 localization"
Author: Liu, Chunxi; Liu, Tingxian; Yu, Xiaoyue; Gu, Yizhu
Title: A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells
  • Document date: 2017_4_1
    • ID: xio0g203_50
    Snippet: After MβCD treatment, the co-localization of TPIC and CAV1 was also evaluated to further determine the important role of caveolae in TPIC internalization. As shown in Fig. 6C , the colocalization of TPIC and CAV1 decreased significantly by pretreatment with MβCD. Without MβCD, CAV1 and TPIC colocalized at the perinuclear area to a large extent. However, after MβCD treatment, cell cholesterol was depleted and the integrity of the caveolae was .....
    Document: After MβCD treatment, the co-localization of TPIC and CAV1 was also evaluated to further determine the important role of caveolae in TPIC internalization. As shown in Fig. 6C , the colocalization of TPIC and CAV1 decreased significantly by pretreatment with MβCD. Without MβCD, CAV1 and TPIC colocalized at the perinuclear area to a large extent. However, after MβCD treatment, cell cholesterol was depleted and the integrity of the caveolae was destroyed. Thereby, the distribution of CAV1 became discontinuous on the cell surface and gathered into a cluster. Consequently, the extent of the co-localization of TPIC and CAV1 was greatly reduced, and only a small number of overlapping spots appeared, suggesting the important effect of caveolae on the internalization of TPIC.

    Search related documents:
    Co phrase search for related documents
    • CAV1 TPIC localization and caveolae important role: 1
    • CAV1 TPIC localization and caveolae integrity: 1
    • CAV1 TPIC localization and caveolae integrity destroy: 1
    • CAV1 TPIC localization and cell cholesterol: 1
    • CAV1 TPIC localization and co CAV1 TPIC localization: 1, 2, 3, 4, 5
    • CAV1 TPIC localization and important role: 1
    • CAV1 TPIC localization and MβCD treatment: 1
    • caveolae important role and cell cholesterol: 1
    • caveolae important role and co CAV1 TPIC localization: 1
    • caveolae important role and important role: 1, 2
    • caveolae important role and MβCD treatment: 1
    • caveolae integrity and cell cholesterol: 1
    • caveolae integrity and co CAV1 TPIC localization: 1
    • caveolae integrity and important role: 1
    • caveolae integrity and MβCD treatment: 1
    • caveolae integrity destroy and cell cholesterol: 1
    • caveolae integrity destroy and co CAV1 TPIC localization: 1
    • caveolae integrity destroy and important role: 1
    • caveolae integrity destroy and MβCD treatment: 1