Author: Ranjbar, Shahin; Haridas, Viraga; Jasenosky, Luke D.; Falvo, James V.; Goldfeld, Anne E.
Title: A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection Document date: 2015_10_22
ID: zy82bo7q_11
Snippet: When we used colony-forming unit (CFU) assay to measure bacterial growth, significant increases (p < 0.01) in MTb growth were observed at 2 and 3 days post-infection in IFITM-KD versus control THP-1 cells ( Figure 2C ), confirming the flow cytometry data we obtained. Furthermore, bacterial uptake was similar in both the IFITM-KD and control THP-1 cells ( Figure 2C ), indicating that the IFITMs restrict MTb at a post-entry stage in human monocytes.....
Document: When we used colony-forming unit (CFU) assay to measure bacterial growth, significant increases (p < 0.01) in MTb growth were observed at 2 and 3 days post-infection in IFITM-KD versus control THP-1 cells ( Figure 2C ), confirming the flow cytometry data we obtained. Furthermore, bacterial uptake was similar in both the IFITM-KD and control THP-1 cells ( Figure 2C ), indicating that the IFITMs restrict MTb at a post-entry stage in human monocytes.
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