Selected article for: "mutation test and synonymous mutation test"
Author: Schlub, Timothy E; Buchmann, Jan P; Holmes, Edward C
Title: A Simple Method to Detect Candidate Overlapping Genes in Viruses Using Single Genome Sequences
  • Document date: 2018_8_7
    • ID: yiqdsf9z_38
    Snippet: This adjustment is analogous to a Bonferroni adjustment of P values, here correcting for the number of ORFs within a reading frame. Small P values for an ORF are interpreted as evidence that the ORF in question is larger than expected by random chance alone and therefore provides evidence that there has been negative selection against mutations that introduce stop codons in this ORF. From this, we can also infer that the ORF is of functional bene.....
    Document: This adjustment is analogous to a Bonferroni adjustment of P values, here correcting for the number of ORFs within a reading frame. Small P values for an ORF are interpreted as evidence that the ORF in question is larger than expected by random chance alone and therefore provides evidence that there has been negative selection against mutations that introduce stop codons in this ORF. From this, we can also infer that the ORF is of functional benefit to the virus. The third test, denoted as the "combined test," requires that the P value for both the codon permutation test and the synonymous mutation test be below some cut-off value.

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