Author: Ranjbar, Shahin; Haridas, Viraga; Jasenosky, Luke D.; Falvo, James V.; Goldfeld, Anne E.
Title: A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection Document date: 2015_10_22
ID: zy82bo7q_4
Snippet: Here, we show that IFITM1, IFITM2, and IFITM3 are transcriptionally activated in response to MTb infection and by several proinflammatory cytokines produced during MTb infection. Strikingly, depletion of these IFITMs significantly enhances MTb growth in human monocytes. Furthermore, IFITM3 co-localizes with the maturing MTb phagosome and its overexpression significantly restricts MTb growth and enhances endosomal acidification in MTb-infected cel.....
Document: Here, we show that IFITM1, IFITM2, and IFITM3 are transcriptionally activated in response to MTb infection and by several proinflammatory cytokines produced during MTb infection. Strikingly, depletion of these IFITMs significantly enhances MTb growth in human monocytes. Furthermore, IFITM3 co-localizes with the maturing MTb phagosome and its overexpression significantly restricts MTb growth and enhances endosomal acidification in MTb-infected cells. These findings provide evidence that IFITM family members directly inhibit a bacterial pathogen.
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