Author: Jobling, Michael G.; Yang, ZhiJie; Kam, Wendy R.; Lencer, Wayne I.; Holmes, Randall K.
Title: A Single Native Ganglioside GM(1)-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway Document date: 2012_10_30
ID: sxdstw4a_19
Snippet: Effects either on binding avidity or on membrane structure and trafficking dynamics could underlie how the CTB subunit, and the other AB 5 toxins, evolved as pentameric structures. This and our other recent studies, however, show that the most fundamental function exploited by CT is to coopt an endogenous glycosphingolipid sorting pathway from the PM to the ER that is essential for toxin entry into the cytosol and the induction of disease......
Document: Effects either on binding avidity or on membrane structure and trafficking dynamics could underlie how the CTB subunit, and the other AB 5 toxins, evolved as pentameric structures. This and our other recent studies, however, show that the most fundamental function exploited by CT is to coopt an endogenous glycosphingolipid sorting pathway from the PM to the ER that is essential for toxin entry into the cytosol and the induction of disease.
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