Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B virus Co-infection

Xiaoping Chen; Qunqun Jiang; Zhiyong Ma; Jiaxin Ling; Wenjia Hu; Qian Cao; Pingzheng Mo; Rongrong Yang; Shicheng Gao; Xien Gui; Yong Xiong; Jinlin Li; Yongxi Zhang

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10. 1101 /2020 CoV-2 has been found to be associated with damage or dysfunction of liver tissue(9, 12-18) and about 14% -53% COVID-19 cases showed liver function damage with abnormal level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Our study is in line with previous observations. We found in COVID-19 cases without HBV infection that about 50.9% (55/108) patients have the dysfunction of liver symptoms by measuring the level of ALT, AST, TBIL, GGT, and ALP during the disease progress. In our enrolled cases, we also discovered that there is higher incidence of abnormal liver function (81.8%, 27/33) in severe COVID-19 patients than did in mild cases (43.3%, 39/90, data not shown), which agrees with the study that lower incidence of AST abnormality was found in the cases diagnosed by CT scan on the subclinical stage than in the COVID-19 patients who were confirmed after onset of symptom(15). Therefore, liver function could be considered as one factor to indicate the progress of COVID-19.