Selected article for: "ACE activity and RAS metabolism"
Author: Hsieh, Wen-Yeh; Kuan, Tang-Ching; Cheng, Kun-Shan; Liao, Yan-Chiou; Chen, Mu-Yuan; Lin, Pei-Heng; Hsu, Yuan-Chang; Huang, Chen-Yi; Hsu, Wei-Hua; Yu, Sheng-Yao; Lin, Chih-Sheng
Title: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions
  • Document date: 2012_10_17
    • ID: zlzig0nn_28
    Snippet: In the present study, major components of RAS and extracellular matrix (ECM) metabolism, pleural ACE, ACE2, MMP-2, and MMP-9, were measured in patients with pleural effusions. Our main findings are: (1) significantly higher the ACE, MMP-9 activity and ACE/ACE2 ratio in exudative effusions; (2) increased MMP-9 and ACE activities combined with decreased ACE2 activity in tuberculous effusion compared to pneumonia and adenocarcinoma effusions. The in.....
    Document: In the present study, major components of RAS and extracellular matrix (ECM) metabolism, pleural ACE, ACE2, MMP-2, and MMP-9, were measured in patients with pleural effusions. Our main findings are: (1) significantly higher the ACE, MMP-9 activity and ACE/ACE2 ratio in exudative effusions; (2) increased MMP-9 and ACE activities combined with decreased ACE2 activity in tuberculous effusion compared to pneumonia and adenocarcinoma effusions. The increased MMP-9 activity found in tuberculous effusion is in agreement with previous reports [9, 14, 15] . Herein, we first report that the changes of ACE and ACE2 activity are associated with tuberculous pleurisy.

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