Author: Hsieh, Wen-Yeh; Kuan, Tang-Ching; Cheng, Kun-Shan; Liao, Yan-Chiou; Chen, Mu-Yuan; Lin, Pei-Heng; Hsu, Yuan-Chang; Huang, Chen-Yi; Hsu, Wei-Hua; Yu, Sheng-Yao; Lin, Chih-Sheng
Title: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions Document date: 2012_10_17
ID: zlzig0nn_31
Snippet: ACE activity was increased (p < 0.001) and ACE2 was decreased (p < 0.05) in tuberculosis specifically, but the ACE and ACE2 activities were no difference between transudate, pneumonia and adenocarcinoma effusions. These results indicated that ACE and ACE2 maybe a biomarker for tuberculosis diagnosis in pleural effusion and it could be emphasized that the increased ACE activity and ratio of ACE/ACE2 in the exudates are mainly contributed from a hi.....
Document: ACE activity was increased (p < 0.001) and ACE2 was decreased (p < 0.05) in tuberculosis specifically, but the ACE and ACE2 activities were no difference between transudate, pneumonia and adenocarcinoma effusions. These results indicated that ACE and ACE2 maybe a biomarker for tuberculosis diagnosis in pleural effusion and it could be emphasized that the increased ACE activity and ratio of ACE/ACE2 in the exudates are mainly contributed from a higher ACE level and lower ACE2 enzyme activities in the tuberculous pleural effusion. In an advanced assay, our data show that the ACE activity of 85% (17/20), 19% (6/32), 18% (5/28) and 18% (8/45) pleural fluids isolated tuberculosis, pneumonia, adenocarcinoma and transudates was > 1 RFU/hour/ml, respectively. It is also indicated that the increased ACE activity found in the exudates are mainly contributed from a higher ACE activity in the tuberculous pleural effusion.
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