Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_5
Snippet: . High rates of post-treatment reinfection, especially in areas of intense transmission, which might require a higher frequency of deworming, in some cases every 4 months or more [10] ; . Lack of efficacy for single-dose albendazole or mebendazole to effect cures or sufficient worm burden reductions against T. trichiura and N. americanus [9, 11, 12] ; . The specter, as yet unproven, of emerging drug resistance; . Failure to fully consider the tra.....
Document: . High rates of post-treatment reinfection, especially in areas of intense transmission, which might require a higher frequency of deworming, in some cases every 4 months or more [10] ; . Lack of efficacy for single-dose albendazole or mebendazole to effect cures or sufficient worm burden reductions against T. trichiura and N. americanus [9, 11, 12] ; . The specter, as yet unproven, of emerging drug resistance; . Failure to fully consider the transmission dynamics of soiltransmitted nematode infections, especially for hookworm [13] , which affects both adult and pediatric populations and would require targeting of both populations for a truly effective elimination strategy [9] ; . Failure to co-implement aggressive programs of sanitation and access to clean water in order to complement deworming [14] .
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