Selected article for: "ace converting enzyme and lung injury"
Author: Hsieh, Wen-Yeh; Kuan, Tang-Ching; Cheng, Kun-Shan; Liao, Yan-Chiou; Chen, Mu-Yuan; Lin, Pei-Heng; Hsu, Yuan-Chang; Huang, Chen-Yi; Hsu, Wei-Hua; Yu, Sheng-Yao; Lin, Chih-Sheng
Title: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions
  • Document date: 2012_10_17
    • ID: zlzig0nn_2
    Snippet: The circulating renin-angiotensin system (RAS) plays a well-described role in maintaining blood pressure homeostasis. Recently, a local tissue-based RAS has also been described and appears to play a key role in injury/repair responses [2, 3] . The expression of RAS components and the elevation of angiotensin converting enzyme (ACE) in a number of lung diseases suggest the existence of a pulmonary RAS and that angiotensin II (Ang II) could mediate.....
    Document: The circulating renin-angiotensin system (RAS) plays a well-described role in maintaining blood pressure homeostasis. Recently, a local tissue-based RAS has also been described and appears to play a key role in injury/repair responses [2, 3] . The expression of RAS components and the elevation of angiotensin converting enzyme (ACE) in a number of lung diseases suggest the existence of a pulmonary RAS and that angiotensin II (Ang II) could mediate, at least in part, the response to lung injury. The central role of ACE is to generate Ang II from Ang I. Ang II is a key effector peptide of RAS that causes vasoconstriction and exerts multiple biological functions. Ang II can also cause the development of interstitial fibrosis via physiological regulation of matrix metalloproteinase (MMP) expression and/or activation [4] .

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