Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_24
Snippet: Ascaris suum utilizes exogenous glucose for energy generation through the glycolytic pathway, and enolase is one of the enzymes catalyzing the synthesis of phosphoenolpyruvate. Ascaris suum enolase (As-Enol-1) was first cloned from an A. suum infective larvae-specific cDNA library using a microarray analysis [46] , and it was also identified as one of the major secreted proteins in A. suum adult ES products that can trigger nitric oxide productio.....
Document: Ascaris suum utilizes exogenous glucose for energy generation through the glycolytic pathway, and enolase is one of the enzymes catalyzing the synthesis of phosphoenolpyruvate. Ascaris suum enolase (As-Enol-1) was first cloned from an A. suum infective larvae-specific cDNA library using a microarray analysis [46] , and it was also identified as one of the major secreted proteins in A. suum adult ES products that can trigger nitric oxide production in macrophages [47] . Specific knockout of As-enol-1 by RNAi resulted in the delay of larval development [48] . Mice immunized with DNA coding for As-Enol-1 exhibited 61% reduction in larvae recovery from lung compared with empty plasmid DNA control, with protection correlated to high levels of specific antibody and lymphoproliferative responses [48] .
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