Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_32
Snippet: As the resistant strains are ideal for examining the natural protective immune response, the susceptible strains are invaluable for efficacy models in vaccine development. For example, AKR mice are attractive for purposes of vaccine development because they are susceptible to infection and yet acquire a protective T H 2 immune response when vaccinated with T. muris ES antigens [51, 52] . Trichuris muris ES proteins and homogenates also elicit pro.....
Document: As the resistant strains are ideal for examining the natural protective immune response, the susceptible strains are invaluable for efficacy models in vaccine development. For example, AKR mice are attractive for purposes of vaccine development because they are susceptible to infection and yet acquire a protective T H 2 immune response when vaccinated with T. muris ES antigens [51, 52] . Trichuris muris ES proteins and homogenates also elicit protective immunity in humanized hu-PBL-SCID mice [56] .
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