Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_40
Snippet: Findings of cross-reactivity and cross-immunity between Trichuris and Trichinella [61] have prompted the study of shared antigens. Using ELISA, immunoprecipitation and immunoblotting, it was demonstrated that T. trichiura-infected mice had cross-reactive antibodies to T. spiralis [61] . Shared stichocyte antigens have also been noted [51] . Among the defined candidate antigens identified from T. spiralis that provide partial protection are an ami.....
Document: Findings of cross-reactivity and cross-immunity between Trichuris and Trichinella [61] have prompted the study of shared antigens. Using ELISA, immunoprecipitation and immunoblotting, it was demonstrated that T. trichiura-infected mice had cross-reactive antibodies to T. spiralis [61] . Shared stichocyte antigens have also been noted [51] . Among the defined candidate antigens identified from T. spiralis that provide partial protection are an aminopeptidase [62] , serine proteases [63] [64] [65] , parasite-derived cytokines [66] , paramyosin [67] , heat-shock protein [65] and 87, 53 and 43 kDa secreted antigens of unknown function [67] [68] [69] .
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