Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_46
Snippet: Selection of the lead candidate antigens will rely on ranking them through a scoring system that assigns a number ranging from 0 to 3, 4 or 5 for each of the critical categories described below. This approach was used previously to rank the leading candidate hookworm antigens used in the Human Hookworm Vaccine [71] . For ascariasis and trichuriasis, the major criteria will include: level of protective immunity; amino acid homology between A. suum.....
Document: Selection of the lead candidate antigens will rely on ranking them through a scoring system that assigns a number ranging from 0 to 3, 4 or 5 for each of the critical categories described below. This approach was used previously to rank the leading candidate hookworm antigens used in the Human Hookworm Vaccine [71] . For ascariasis and trichuriasis, the major criteria will include: level of protective immunity; amino acid homology between A. suum and A. lumbricoides or T. muris and T. trichiura; known or presumed mechanism of action; absence of prevaccination IgE among an endemic population; solubility and stability; and expression yield.
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