Amylmetacresol/2,4-dichlorobenzyl alcohol, hexylresorcinol, or carrageenan lozenges as active treatments for sore throat

Morokutti-Kurz, Martina; Graf, Christine; Prieschl-Grassauer, Eva

The antiviral effect of carrageenan is conferred through direct binding of the polymer to viral particles. 7 To assay the time dependency of this interaction, two representative respiratory viruses (influenza virus A H1N1n and hCoV OC43) were incubated with iota-carrageenan beads. At different time points the beads/virus complexes were separated from the solution by centrifugation; the remaining virus in the supernatant was quantified using a classical HA assay. Within 3 minutes, the initial viral load of 3.03e4 influenza virus and 9.43e6 hCoV OC43 particles/well is reduced by 57% and 82%; within 10 minutes by 72% and 91%, respectively. After 20 minutes, the viral load drops below the detection limit ( Figure 2 ). The medium dissolution time of the lozenge in the mouth was determined to be 13 minutes and 20 seconds. During this period, the viral titer is reduced by 85% and 91% for influenza virus A and hCoV OC43, respectively.