Author: Mayla Borba; Fernando de Almeida Val; Vanderson Sousa Sampaio; Marcia Araujo Alexandre; Gisely Cardoso Melo; Marcelo Brito; Maria Mourao; Jose Diego Brito Sousa; djane Baia-da-Silva; Marcus Vinitius Farias Guerra; Ludhmila Hajjar; Rosemary Costa Pinto; Antonio Balieiro; Felipe Gomes Naveca; Mariana Xavier; Alexandre Salomao; Andre Siqueira; Alexandre Schwarzbolt; Julio Henrique Rosa Croda; Mauricio Lacerda Nogueira; Gustavo Romero; Quique Bassat; Cor Jesus Fontes; Bernardino Albuquerque; Claudio Daniel-Ribeiro; Wuelton Monteiro; Marcus Lacerda
Title: Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study) Document date: 2020_4_11
ID: ifxm3j4y_63
Snippet: History of heart disease was more frequent among patients receiving the higher CQ dosage (p=0.05). Occurrence of myocarditis (defined as CKMB higher than 2x the upper normal limit), which may be a final complication of severe sepsis or a lesion triggered by the virus itself, was seen in 2/24 (8.3%) patients (1 patient/arm). No echocardiogram was performed timely......
Document: History of heart disease was more frequent among patients receiving the higher CQ dosage (p=0.05). Occurrence of myocarditis (defined as CKMB higher than 2x the upper normal limit), which may be a final complication of severe sepsis or a lesion triggered by the virus itself, was seen in 2/24 (8.3%) patients (1 patient/arm). No echocardiogram was performed timely.
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