Author: Feng, Joy Y
Title: Addressing the selectivity and toxicity of antiviral nucleosides Document date: 2018_3_13
ID: uajl5wyk_7
Snippet: Due to their mechanism of action, nucleoside analogs are generally evaluated for 5-8 days in both replicating laboratory-adapted cell lines and non-replicating primary cells. 18 A standard readout is the effect of compound on the ATP level within the cells. We found that among 20þ laboratory-adapted cells we tested, prostate cancerderived PC-3 cells and T-cell leukemia-derived MT4 cells are generally the most sensitive to toxins, and are signifi.....
Document: Due to their mechanism of action, nucleoside analogs are generally evaluated for 5-8 days in both replicating laboratory-adapted cell lines and non-replicating primary cells. 18 A standard readout is the effect of compound on the ATP level within the cells. We found that among 20þ laboratory-adapted cells we tested, prostate cancerderived PC-3 cells and T-cell leukemia-derived MT4 cells are generally the most sensitive to toxins, and are significantly more sensitive than HepG2 cells, a widely used cell line for in vitro toxicity studies. In addition, we found that laboratory-adapted cells are as useful for detecting potential toxicity liabilities as primary cells.
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