Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_36
Snippet: Homogenized adult T. muris antigens, either emulsified in Freund's complete adjuvant for subcutaneous immunization, or combined with cholera toxin for oral administration, have been administered to several different mouse strains [57] . While the mucosal response was enhanced by oral vaccination, this was not sufficient for protection against infection in the low responders; in other words, protection was achieved only in the BALB/c high-responde.....
Document: Homogenized adult T. muris antigens, either emulsified in Freund's complete adjuvant for subcutaneous immunization, or combined with cholera toxin for oral administration, have been administered to several different mouse strains [57] . While the mucosal response was enhanced by oral vaccination, this was not sufficient for protection against infection in the low responders; in other words, protection was achieved only in the BALB/c high-responder mice [57] , a result similarly found in oral vaccination for Trichinella leading to only protective immunity in high-responder mice [57] . In contrast, subcutaneous administration provided protective immunity in multiple strains [57, 58] . In vaccinated humanized mice, an immunodominant 66 kDa T. muris antigen was identified from worm homogenates [15] .
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