Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_10
Snippet: DENV RdRp is essential for viral replication and there are no similar enzymes found in the host. This enzyme, then, is considered to be a prime target for antiviral development [12] . Nucleoside-based prodrug antivirals have been investigated. These agents are phosphorylated in vivo, and then target the active site of the RdRp enzyme [20] . Nonnucleoside small molecules can inhibit viral RdRp by binding to allosteric sites of the protein [19] ......
Document: DENV RdRp is essential for viral replication and there are no similar enzymes found in the host. This enzyme, then, is considered to be a prime target for antiviral development [12] . Nucleoside-based prodrug antivirals have been investigated. These agents are phosphorylated in vivo, and then target the active site of the RdRp enzyme [20] . Nonnucleoside small molecules can inhibit viral RdRp by binding to allosteric sites of the protein [19] .
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