Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_2
Snippet: Currently, there are no treatment options for dengue fever; there is no known cure or vaccine. There are, however, several dengue virus proteins that have been identified as potential drug targets [12] . Natural products have been and continue to be excellent sources of medicinal agents, as themselves or as templates for synthetic agents [13] . The people of developing nations often have limited access to health care and inadequate resources for .....
Document: Currently, there are no treatment options for dengue fever; there is no known cure or vaccine. There are, however, several dengue virus proteins that have been identified as potential drug targets [12] . Natural products have been and continue to be excellent sources of medicinal agents, as themselves or as templates for synthetic agents [13] . The people of developing nations often have limited access to health care and inadequate resources for pharmaceuticals, and traditional herbal medicines offer the potential for treatments of diseases in these regions. In this work, we have screened our virtual library of phytochemicals against several protein targets of dengue virus [14] , included dengue virus protease (NS2B-NS3pro), helicase (NS3 helicase), methyltransferase (MTase), RNA-dependent RNA polymerase (RdRp), and the dengue virus envelope protein (Ep), using a molecular docking approach.
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