Selected article for: "LD lethal dose and lethal dose"
Author: WU, Hong-Xia; WANG, Hua-Lei; GUO, Xiao-Feng; YANG, Yu-Jiao; MA, Jin-Zhu; WANG, Tie-Cheng; GAO, Yu-Wei; ZHAO, Yong-Kun; YANG, Song-Tao; XIA, Xian-Zhu
Title: Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo
  • Document date: 2013_6_14
    • ID: sj9k4c3i_21
    Snippet: Post-exposure vaccination is obligatory in all cases as treatment after human exposure to infected animal bites. Regarding whether rAAV-N796 could protect mice exposed to RABV infection within 24 hr, the mice were first intramuscularly challenged with a lethal dose (20 LD 50 ) of RAbV CVS-11 and were then injected with rAAV-N796 intracerebrally and intramuscularly 24 hr later. The results (Fig. 3D) showed that there was a partial protection (25 Â.....
    Document: Post-exposure vaccination is obligatory in all cases as treatment after human exposure to infected animal bites. Regarding whether rAAV-N796 could protect mice exposed to RABV infection within 24 hr, the mice were first intramuscularly challenged with a lethal dose (20 LD 50 ) of RAbV CVS-11 and were then injected with rAAV-N796 intracerebrally and intramuscularly 24 hr later. The results (Fig. 3D) showed that there was a partial protection (25 ± 4.1%) and no protection in mice treated with rAAV-Neg. The N gene mRNA level in the rAAV-N796-treated mouse brain was significantly decreased compared with the control (Fig. 3E) .

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