Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_22
Snippet: As37 is an immunodominant A. suum larval surface antigen recognized by pig immune serum [43, 44] . The molecule, which contains multiple immunoglobulin-like domains, is also found in adult worms. An A. lumbricoides ortholog has been cloned (Al37) and found to exhibit 91% amino acid homology with As37. The molecule elicited 69% reduction in larvae from the liver and lungs following A. lumbricoides egg challenge [45] ......
Document: As37 is an immunodominant A. suum larval surface antigen recognized by pig immune serum [43, 44] . The molecule, which contains multiple immunoglobulin-like domains, is also found in adult worms. An A. lumbricoides ortholog has been cloned (Al37) and found to exhibit 91% amino acid homology with As37. The molecule elicited 69% reduction in larvae from the liver and lungs following A. lumbricoides egg challenge [45] .
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