Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_30
Snippet: Trichuris trichiura is a parasite of the superfamily Trichinelloidea, known as the common whipworm of humans and nonhuman primates. Due to its host specificity, there is no established laboratory animal model for this pathogen. Fortunately, the closely related Trichuris muris parasite, specific for rats and mice, has emerged as a useful surrogate for immunogenicity and efficacy models. Additionally, animal models for Trichinella spiralis (a cause.....
Document: Trichuris trichiura is a parasite of the superfamily Trichinelloidea, known as the common whipworm of humans and nonhuman primates. Due to its host specificity, there is no established laboratory animal model for this pathogen. Fortunately, the closely related Trichuris muris parasite, specific for rats and mice, has emerged as a useful surrogate for immunogenicity and efficacy models. Additionally, animal models for Trichinella spiralis (a cause of trichinellosis), also a member of the Trichinelloidea superfamily, exhibit some immunological similarities for Trichuris sp. Both Trichuris sp. and Trichinella sp. possess a unique stichosome -a modified esophagus and esophageal gland that contains longitudinally arranged cells known as stichocytes -which is a rich source of ES Photo courtesy of Florian Rö ber, originally published in [85] Ó Florian Rö ber.
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