Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_20
Snippet: The binding site of DENV NS2B-NS3 protease involves the catalytic triad of Ser196, His112, and Asp136. Additional amino acids at the active site are Glu46, Ile97, and Glu47. The binding site of this serine protease, as evidenced by the NMR structure with bound dipeptide Lys-Arg (PDB 2M9Q) [24] , is bounded by Glu46 and Glu47, which both form electrostatic ionic interactions with the NH 3 + moiety of Lys-Arg. Other amino acids at the binding site .....
Document: The binding site of DENV NS2B-NS3 protease involves the catalytic triad of Ser196, His112, and Asp136. Additional amino acids at the active site are Glu46, Ile97, and Glu47. The binding site of this serine protease, as evidenced by the NMR structure with bound dipeptide Lys-Arg (PDB 2M9Q) [24] , is bounded by Glu46 and Glu47, which both form electrostatic ionic interactions with the NH 3 + moiety of Lys-Arg. Other amino acids at the binding site include Val113, Ile97, Gln88, and Ile91.
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