Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_26
Snippet: The balsacones A-C are antibacterial dihydrochalcones from Populus balsamifera [52] . We are unaware of any antiviral properties of these compounds, but they do exhibit excellent docking properties to DENV NS2B-NS3 protease ( Table 1 ) and DENV helicase (see below, Table 2 ). The prenylated flavonoids glabranine and 7-O-methylglabranine, isolated from Tephrosia spp., had shown in-vitro antiviral activity against dengue virus serotype 2 [53] . Alt.....
Document: The balsacones A-C are antibacterial dihydrochalcones from Populus balsamifera [52] . We are unaware of any antiviral properties of these compounds, but they do exhibit excellent docking properties to DENV NS2B-NS3 protease ( Table 1 ) and DENV helicase (see below, Table 2 ). The prenylated flavonoids glabranine and 7-O-methylglabranine, isolated from Tephrosia spp., had shown in-vitro antiviral activity against dengue virus serotype 2 [53] . Although these two flavonoids were not among the strongest docking, they did show docking selectivity with DENV protease (E dock = -113.4 and -118.8 kJ/mol, respectively). Two diprenylated flavanones, euchrestaflavanone A from Macaranga pleiostemona [54] and flemiflavanone D from Flemingia stricta [55] showed notably strong docking with DENV NS2B-NS3 protease ( Table 1) . These compounds had shown antibacterial activity, but to our knowledge have not been screened for anti-dengue activity.
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