Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_6
Snippet: DENV NS3 helicase is an essential enzyme for viral replication and has been identified as a potential drug target. The enzyme shows both ATP-hydrolysis activity as well as RNA duplex unwinding activity. These two enzymatic activities are likely coupled with ATPase activity providing the chemical energy for RNA unwinding. Thus, there are two potential targets for DENV NS3 helicase, the RNA binding site [18] and the ATP binding site [12] ......
Document: DENV NS3 helicase is an essential enzyme for viral replication and has been identified as a potential drug target. The enzyme shows both ATP-hydrolysis activity as well as RNA duplex unwinding activity. These two enzymatic activities are likely coupled with ATPase activity providing the chemical energy for RNA unwinding. Thus, there are two potential targets for DENV NS3 helicase, the RNA binding site [18] and the ATP binding site [12] .
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