Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_25
Snippet: Glycyrrhiza extracts have shown antiviral activity against human immunodeficiency virus [47, 48] , Newcastle disease virus [49] , human respiratory syncytial virus [50] and herpes simplex virus 1 [51] . Prenylated stilbenoids (3,3 ,4,5tetrahydroxy-5-prenylbibenzyl, 3,3 ,5 -trihydroxy-4methoxy-5-prenylbibenzyl, 3-acetoxy-4 ,5-dihydroxy-3prenyldihydrostilbene, licobenzofuran) and isoflavonoids (glycyrrhisoflavone, 4 -O-methylglycyrrhisoflavone) cha.....
Document: Glycyrrhiza extracts have shown antiviral activity against human immunodeficiency virus [47, 48] , Newcastle disease virus [49] , human respiratory syncytial virus [50] and herpes simplex virus 1 [51] . Prenylated stilbenoids (3,3 ,4,5tetrahydroxy-5-prenylbibenzyl, 3,3 ,5 -trihydroxy-4methoxy-5-prenylbibenzyl, 3-acetoxy-4 ,5-dihydroxy-3prenyldihydrostilbene, licobenzofuran) and isoflavonoids (glycyrrhisoflavone, 4 -O-methylglycyrrhisoflavone) chalcones (kanzonol Y) from G. glabra have demonstrated outstanding docking properties to DENV protease (Table 1) . Prenylated phenolics from G. glabra have inhibited HIV giant cell formation [47] . In addition, kanzonol Y docked well with DENV RNA-dependent RNA polymerase and DENV envelope protein (see below). Glabraisoflavanone, also from G. glabra, docked well with DENV methyltransferase (see below).
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